PAIN MANAGEMENT
A number of different, unpleasant side effects can result when a patient is a poor metabolizer of certain opioids and anti-anxiety medications. Additionally, if a patient is an ultra-rapid metabolizer of certain opioid medications, they may appear to be abusing or drug-seeking when, in fact, they are simply not receiving their optimal dose of medication.
MEDICATIONS OF CONCERN
- MEDICATION – GENE
- Fentanyl – CYP3A4, CYP3A5
- Codeine – CYP2D6
- Hydrocodone – CYP2D6
- Oxycodone – CYP2D6
- Alprazolam – CYP3A4
- Diazepam – CYP2C19
- *And many more
MENTAL HEALTH
Finding the right psychiatric drug at the right dose has long been an art form for mental health professionals due to the plethora of options. Sometimes, with more difficult cases, patients can suffer needlessly for months only to find that the medication they have been prescribed is ineffective or carries a serious and lifestyle-altering side effect. By administering the Summit Drug Metabolism Test, psychiatrists and mental health professionals can have more data at their disposal to determine which medications will work best for their patients, shortening treatment time dramatically and limiting potentially harmful side effects.
MEDICATIONS OF CONCERN:
- Alprazolam- CYP3A4
- Citalopram – CYP2C19
- Escitalopram – CYP2C19
- L-Methylfolate – MTHFR
- Amitriptyline – CYP2C19, CYP2D6
- Aripiprazole – CYP2D6
- Aripiprazole – CYP2D6
- *And many more
CARDIOLOGY
Warfarin and other medications used in the treatment of cardiac conditions have long been known to be extremely dangerous if not prescribed and administered properly. For cardiologists, having a patient’s genetic information is of the utmost importance. Clopidogrel, an extremely popular and effective antiplatelet agent, even has an FDA Black-Box Warning stressing that CYP2C19 Poor Metabolizers (up to 14% of all patients) are at high risk for treatment failure.
MEDICATIONS OF CONCERN:
- Warfarin- CYP2C9, VKORC1
- Clopidigrel- CYP2C19
- Atorvastatin- CYP3A4
- Lopressor- CYP2D6, CYP3A4
- *And many more
ADDICTION & RECOVERY
Many of the medications used in conjunction with treatment programs will vary in effectiveness from person to person due to each individual’s genetic profile.
MEDICATIONS OF CONCERN:
- Methadone- CYP2B6
- Naltrexone – OPRM1
- Buprenorphine – CYP3A4
- *And many more
LONG-TERM CARE
For patients in long-term care or assisted living situations, Drug Metabolism Testing is of the utmost importance. Often, patients in these situations are taking multiple drugs at one time. This can put the patient at risk for serious side-effects and lack of efficacy of treatment depending on their metabolizer type. Our Drug Metabolism Reports can help you through the maze.
MEDICATIONS OF CONCERN:
- Aripiprazole – CYP2D6
- Risperidone – CYP2D6
- Warfarin- CYP2C9, VKORC1
- Lorazepam – CYP3A4
- *And many more
PRIMARY CARE
Primary care providers are often the “quarterback” for their patients, managing a wide array of different prescriptions from both themselves and other specialists. Summit’s Drug Metabolism Report can help each Clinician understand which medications will be most effective for each patient, which could be harmful, how to hone in on optimal dosage, and which medications, used in conjunction, could diminish the effects of others.
MEDICATIONS OF CONCERN:
- Clopidogrel- CYP2C19
- Simvastatin – CYP3A4
- Omeprazole – CYP2C19
- Hydrocodone – CYP3A4, CYP2D6
- *And many more